Spark won FDA’s first approval on gene therapy for genetic disease more than one year ago, treating retinal dystrophy (by mutations on the RPE65 gene) with LUXTURNA. The treatment carries a list price of $850,000, or $425,000 per eye.
Besides, Spark Therapeutics has SPK-8011 in clinical trials, a novel gene therapy for the treatment of haemophilia A, which is expected to start Phase 3 in 2019.
California Governor Gavin and Attorney General Xavier Becerra today filed a lawsuit in the U.S. District Court for the Northern District of California challenging President Trump’s declaration of a national emergency and his attempt to divert funding appropriated by Congress for other purposes.
Joining Attorney General Becerra in filing the lawsuit are the attorneys general of Colorado, Connecticut, Delaware, Hawai’i, Illinois, Maine, Maryland, Michigan, Minnesota, Nevada, New Jersey, New Mexico, New York, Oregon, and Virginia.
Trump anticipated lawsuits – “We will have a national emergency, and we will then be sued. And they will sue us in the Ninth Circuit, even though it shouldn’t be there,” the president said, referring to the nation’s largest circuit court whose area encompasses California. “And we’ll possibly get a bad ruling and then we’ll get another bad ruling and then we’ll end up the Supreme Court, and then hopefully we’ll get a fair shake and we’ll win in the Supreme Court, just like the ban.”
To start with, Siemens made 2 acquisitions in 2018 – Enlightened Inc. and J2 Innovations – before acquiring Comfy, mentioned in the previous post.
Enlightened – Iot: lightening sensors and more
Three main applications: lightening, HVAC system (heating, a ventilation, and air-conditioning), space utilization.
For example the lightening system, built on IoT architecture, consists of a network of LED lights and their patented sensors connected together to form a sensor and analytics platform. Data is collected 65 times/second to detect environmental and occupancy changes and take action on lighting needs in real-time.
Created FIN (Fluid INtegration) Framework, an open framework for building automation and IoT applications. It is used as an integration layer and itself doesn’t design/manufacture IoT devices.
According to its website, it employs an applications server technology with tagging and data modeling. FIN is a HTML5 browser based unified toolset optimized for efficient workflows.
Before Amazon’s move, in Oct 2017, Assa Abloy, the $23 billion Swedish lock giant that owns Yale and many other brands — announced that it is buying US-based smart lock maker August Home to double down on new technology. (TechCrunch)
Sigfox – IoT: Platform
Based in Europe, Sigfox is designing a Low Power Wide Area network (Ultra Narrow Band radio operating in the unlicensed bands) for IoT connectivity.
And of course the products to centralize data from big tech companies with Amazon and Google the most aggressive ones.